I am using it on Vista and have no issues. One thing I found unclear when first starting was if I needed to use the mce replacement driver for Vista but this was not the case. All I had to do was make the registry changes which was my preferred method because you retain the ability to wake the computer from hibernate/sleep that is lost when using the replacement driver. You could also try HIP but I found IR Server suite much easier to setup/customize and have had zero issues with it.